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Nature is the international weekly journal of science: a magazine style journal that publishes full-length research papers in all disciplines of science, as well as News and Views, reviews, news, features, commentaries, web focuses and more, covering all branches of science and how science impacts upon all aspects of society and life.
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Structure, function and pharmacology of human itch GPCRs

Mer, 17/11/2021 - 00:00

Nature, Published online: 17 November 2021; doi:10.1038/s41586-021-04126-6

Structural studies of the itch receptors MRGPRX2 and MRGPRX4 in complex with endogenous and synthetic ligands provide a basis for the development of therapeutic compounds for pain, itch and mast cell-mediated hypersensitivity.

Cardiopharyngeal deconstruction and ancestral tunicate sessility

Mer, 17/11/2021 - 00:00

Nature, Published online: 17 November 2021; doi:10.1038/s41586-021-04041-w

The heart of appendicularians has evolved by 'deconstructing' an ancestral ascidian-like gene regulatory network.

Isolation and characterization of a californium metallocene

Mer, 17/11/2021 - 00:00

Nature, Published online: 17 November 2021; doi:10.1038/s41586-021-04027-8

Chemical experiments on californium are stymied by isotope availability and radioactivity considerations, but are advanced here with synthesis and characterization of an organometallic complex.

Approaching the intrinsic exciton physics limit in two-dimensional semiconductor diodes

Mer, 17/11/2021 - 00:00

Nature, Published online: 17 November 2021; doi:10.1038/s41586-021-03949-7

Two-dimensional transition metal dichalcogenide diodes with defect-free van der Waals contacts allows minimization of the extrinsic interfacial disorder-dominated recombination and access to the intrinsic excitonic behaviour in two-dimensional semiconductor devices.

Structure, function and pharmacology of human itch receptor complexes

Mer, 17/11/2021 - 00:00

Nature, Published online: 17 November 2021; doi:10.1038/s41586-021-04077-y

Cryo-electron microscopy structures of the MRGPRX2–Gi1 trimer in complex with polycationic compound 48/80 or inflammatory peptides provide insights into the sensing of cationic allergens by MRGPRX2, potentially facilitating the design of therapies to prevent unwanted pseudoallergic reactions.

Exploding and weeping ceramics

Mer, 17/11/2021 - 00:00

Nature, Published online: 17 November 2021; doi:10.1038/s41586-021-03975-5

A study demonstrates that a range of different behaviours—from reversible, through weeping, to explosive—can be exhibited by a chemically homogeneous ceramic system by manipulating conditions of compatibility in unusual ways.

Reverse-translational identification of a cerebellar satiation network

Mer, 17/11/2021 - 00:00

Nature, Published online: 17 November 2021; doi:10.1038/s41586-021-04143-5

Activity in anterior deep cerebellar nuclei reduces food consumption in mice without reducing metabolic rate, potentially identifying a therapeutic target for disorders involving excessive eating.

Cortical responses to touch reflect subcortical integration of LTMR signals

Mer, 17/11/2021 - 00:00

Nature, Published online: 17 November 2021; doi:10.1038/s41586-021-04094-x

Genetic manipulation of skin peripheral sensory neurons in mice shows that cortical neuron responses to touch reflect subcortical mixing of signals from both rapidly adapting and slowly adapting low-threshold mechanoreceptors.

Mental health concerns during the COVID-19 pandemic as revealed by helpline calls

Mer, 17/11/2021 - 00:00

Nature, Published online: 17 November 2021; doi:10.1038/s41586-021-04099-6

Data collected from crisis helplines during the COVID-19 pandemic show that pandemic-related issues replaced rather than exacerbated underlying anxieties, and demonstrate that helpline data are useful indicators of public mental health.

Herpesviruses assimilate kinesin to produce motorized viral particles

Mer, 17/11/2021 - 00:00

Nature, Published online: 17 November 2021; doi:10.1038/s41586-021-04106-w

Herpes simplex virus type I and pseudorabies virus assimilate kinesin from host epithelial cells and repurpose the motor to traffic to the nuclei of neurons in the peripheral nervous system.

Observation of Stark many-body localization without disorder

Mer, 17/11/2021 - 00:00

Nature, Published online: 17 November 2021; doi:10.1038/s41586-021-03988-0

Experiments with a trapped-ion quantum simulator observe Stark many-body localization, in which the quantum system evades thermalization despite having no disorder.

Single-cell transcriptomic characterization of a gastrulating human embryo

Mer, 17/11/2021 - 00:00

Nature, Published online: 17 November 2021; doi:10.1038/s41586-021-04158-y

The single-cell transcriptional profile of a human embryo between 16 and 19 days after fertilization reveals parallels and differences in gastrulation in humans as compared with mouse and non-human primate models.

Measuring phonon dispersion at an interface

Mer, 17/11/2021 - 00:00

Nature, Published online: 17 November 2021; doi:10.1038/s41586-021-03971-9

Four-dimensional electron energy-loss spectroscopy measurements of the vibrational spectra and the phonon dispersion at a heterointerface show localized modes that are predicted to affect the thermal conductance and electron mobility.

Excitons and emergent quantum phenomena in stacked 2D semiconductors

Mer, 17/11/2021 - 00:00

Nature, Published online: 17 November 2021; doi:10.1038/s41586-021-03979-1

This Review discusses the exciton physics of transition metal dichalcogenides, focusing on moiré patterns and exciton many-body physics, and outlines future research directions in the field.

Widespread changes in surface temperature persistence under climate change

Mer, 17/11/2021 - 00:00

Nature, Published online: 17 November 2021; doi:10.1038/s41586-021-03943-z

A survey of climate change simulations from different models indicates widespread changes in surface temperature persistence under global warming that may be attributable to a broad range of physical processes.

Structural insights into Ubr1-mediated N-degron polyubiquitination

Mer, 17/11/2021 - 00:00

Nature, Published online: 17 November 2021; doi:10.1038/s41586-021-04097-8

Structures of Ubr1 in complex with Ubc2, ubiquitin and two N-degron peptides reveal a Ubc2-binding region and an acceptor ubiquitin-binding loop on Ubr1, providing mechanistic insights into the initiation and elongation steps of ubiquitination catalysed by Ubr1.

A critical mass of learning at Mila, Canada

Mer, 17/11/2021 - 00:00

Nature, Published online: 17 November 2021; doi:10.1038/d41586-021-03064-7

Attracted by generous funding and big names, a hub for leading talent in artificial intelligence is thriving in Montreal.

The start-ups chasing clean, carbon-free fusion energy

Mer, 17/11/2021 - 00:00

Nature, Published online: 17 November 2021; doi:10.1038/d41586-021-03401-w

An emerging industry of nuclear-fusion firms promises to have commercial reactors ready in the next decade.

Californium—carbon bond captured in a complex

Mer, 17/11/2021 - 00:00

Nature, Published online: 17 November 2021; doi:10.1038/d41586-021-03385-7

The scarcity and high radioactivity of the heaviest actinide elements, such as californium, make their study a formidable challenge. A landmark report describes the first structural characterization of a californium—carbon bond.

Canada’s scientists are elucidating the dark metabolome

Mer, 17/11/2021 - 00:00

Nature, Published online: 17 November 2021; doi:10.1038/d41586-021-03062-9

Teams studying the human body at the molecular level are grappling with matter that defies identification.